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Cytological profiling heat map.

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posted on 2017-06-13, 17:29 authored by Dina Hajjar, Stephan Kremb, Salim Sioud, Abdul-Hamid Emwas, Christian R. Voolstra, Timothy Ravasi

Automated HCS was used to assess compound-related perturbations of human cells using a full set of cellular markers. To assign possible biological targets to the test compounds, we compared the resulting cytological profiles to profiles retrieved from reference compounds with known modes of action. Some of the plant fraction extracts closely matched FDA-approved anticancer drugs and clustered with topoisomerase inhibitors. Individual features are presented on the x-axis and individual compounds are presented on the y-axis.