Cytokine levels in the cortex of TG and WT mice 9 months post-irradiation.
figureposted on 2017-11-29, 18:23 authored by Emil Rudobeck, John A. Bellone, Attila Szücs, Kristine Bonnick, Shalini Mehrotra-Carter, Jerome Badaut, Gregory A. Nelson, Richard E. Hartman, Roman Vlkolinský
Expression of CXCL10 and CCL2 was significantly higher in TG mice than in WT mice, but irradiation had no further effect on these cytokines. The differences in TNFα, IL-1β and IL-6 expression were not statistically significant (NS) in either TG or WT mice. TG mice: N = 6, 6, 5, 5 animals/radiation group; WT mice: N = 7, 8 animals/radiation group. Statistical analyses: 2-way ANOVA, genotype effect ††† p<0.001, † p<0.05. Data represent means ± SEM.
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CCL9 months post-irradiationWT miceWMLow-dose proton radiation effectsspace travel Space radiationGround-based animal studiesAPPsynaptic transmissionTG micepresynaptic marker synaptophysinCXCLbead-based multiplex assayspace radiation spectrumβ deposition6 months post-irradiationCA 1 neuronsADTNFILpro-inflammatory cytokine levels