Cross-section of a bilayered duct

figure

posted on 2011-12-30, 15:16 authored by Melissa C Adriance, Jamie L Inman, Ole W Petersen, Mina J Bissell

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Taken from "Myoepithelial cells: good fences make good neighbors"

Breast Cancer Research 2005;7(5):190-197.

Published online 12 Jul 2005

PMCID:PMC1242144.

Secretory luminal cells (LEPs) are apically located to contractile myoepithelial cells (MEPs) and the basement membrane (BM). Milk proteins and cleaved Muc1 are secreted into the luminal space during lactation. Desmosomes containing desmoglein (Dsg)2 and desmocollin (Dsc)2 form between adjacent luminal cells and between adjacent LEPs and MEPs. Desmosomes between MEPs contain Dsg3 and Dsc3. MEPs as contractile cells contain smooth muscle actin and adhere to the BM via hemidesmosomes.

Cross-section of a bilayered duct

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