Correlation between the intensity of sprouting and the percentage of the nuclei with Bdnf alleles at the nuclear periphery.

A) Mossy fiber sprouting was verified by immunofluorescent staining for synaptoporin in the molecular layer of DG region of the hippocampus. Representative pictures of different levels of sprouting of animals at 4 weeks after administration of kainate are shown. B) Percentage of animals showing different levels of synaptoporin staining intensity scored in 5-grade scale (0-lack of sprouting- 4 very strong sprouting). C) Correlation between the levels of sprouting in the DG, 4 weeks from the administration of kainate, measured in 5- grade scale, and percentage of the nuclei with Bdnf alleles localized at the nuclear periphery. Scale Bar: 100 μm.