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Correlation between gene expression and average CpG methylation rates at CpG island shores.

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posted on 2020-09-29, 17:32 authored by Risa Mitsumori, Kazuya Sakaguchi, Daichi Shigemizu, Taiki Mori, Shintaro Akiyama, Kouichi Ozaki, Shumpei Niida, Nobuyoshi Shimoda

Methylation rates in AD-related DMRs in CR1, CLU, and PICALM were plotted against the expression levels of CR1, CLU, and PICALM. Relationships were analyzed based on Pearson’s correlation coefficient. The numbers of samples examined are shown in parentheses. All methylation rates were quantified at the same regions as in Fig 2 by Sanger sequencing.

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Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer’s disease patients
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ABCAAUCBINAPOECR 1study implicates methylation differ...CLU methylation levelsCpG island shoresAD-associated genesDNA methylation levelsPICALM48 AD patients

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