Conservation of TgApiCox13/HsMiNT protein features across eukaryotic evolution.

An illustrative phylogenetic tree based on currently accepted models for eukaryotic evolution [54]. Branches were coloured based on whether the ApiCox13 homologs of clade members contain a C-terminal transmembrane domain (TMD, pink) and/or an N-terminal mitochondrial targeting peptide (mTP, green) (S1 Table). Possible points at which TMD or mTP features were gained are indicated by coloured circles.

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