Consequences of replication fork stalling at secondary structures

Copyright information:

Taken from "Inverted repeat-stimulated sister-chromatid exchange events are -independent but reduced in a mutant"

Nucleic Acids Research 2005;33(16):5243-5249.

Published online 15 Sep 2005

PMCID:PMC1216339.

© The Author 2005. Published by Oxford University Press. All rights reserved

() Pausing at the replication fork can lead to template switching. Template switching can form a wild-type gene. The large loop must be preserved from mismatch repair until the next round of DNA replication, or else be repaired in favor of loop retention, to generate a His cell. (). A DSB formed due to nicking of the secondary structure within the triplet repeat sequence may be repaired by an intra-chromosomal single-strand annealing-like event, leading to contraction of the repeat tract. The hatch marks represent the repeated units.