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Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways - Fig 1

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posted on 2016-12-15, 19:07 authored by So Youn Park, Hae Young Kim, Hee Jeong Park, Hwa Kyoung Shin, Ki Whan Hong, Chi Dae Kim

Aa and Ab. Increased intracellular accumulations of Aβ and C-terminal fragment β (C99) in N2a Swe cells. B. Time-dependent increases in the expression of JAK2 phosphorylated at Tyr1007/1008 (P-JAK2) in activated N2a Swe cells. C and D. Concentration-dependent decreases in P-JAK2 expression by taxifolin (10 ~ 50 μM), cilostazol (10 ~ 50 μM), and 20 μM AG490 (a JAK2 inhibitor) determined after culture in medium containing 1% FBS for 3 hr. JAK2 levels showed little change. E. Co-treatment with 10 μM taxifolin plus 10 μM cilostazol significantly decreased P-JAK2 expression. Results are the means ± SEM of 4–5 experiments. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Zero time; ##P < 0.01, ###P < 0.001 vs. Vehicle (Veh); $ $ $P < 0.001 vs. 10 μM Cilostazol alone; ††† P < 0.001 vs. 10 μM Taxifolin alone.