Computational modeling schematics.
(A) Molecules at the cell membrane and a thin slice of adjacent cytoplasm are simulated explicitly. Both compartments are modeled as 2D surface. (B) In the quasi-3D simulations, a well-stirred compartment representing bulk cytoplasm is added to approximate 3D effects. (C) Reaction scheme for a Turing-type model of Cdc42-dependent yeast polarity establishment from Goryachev and Polkhilko .