Complement cascade diagram

This is a simplified diagram of complement activation resulting in the membrane attack complex. Regardless of the initial activation pathway, the majority of complement activation may be through the alternative pathway feedback loop.

High quality diagram based on Brodky 2009 diagrams.

Brodsky R. Paroxysmal nocturnal hemoglobinuria. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al., editors. Hematology: Basic Principles and Practice. Philadelphia, PA: Churchill Livingstone; 2009. p. 385-394.