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Comparisons of model predictions to experimental data using a fixed elimination rate model with hepatic sequestration () and an inducible elimination rate model with () and without () hepatic sequestration

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posted on 31.12.2011, 02:38 by Claude Emond, Linda S. Birnbaum, Michael J. DeVito

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Taken from "Use of a Physiologically Based Pharmacokinetic Model for Rats to Study the Influence of Body Fat Mass and Induction of CYP1A2 on the Pharmacokinetics of TCDD"

Environmental Health Perspectives 2006;114(9):1394-1400.

Published online 18 Apr 2006


This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI

EXBL, experimental blood levels. Model predictions were compared with the data of , where female rats were exposed to a single oral dose of 10 μg of TCDD/ kg BW. Error bars are ± SD.


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