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Comparison of the number of CD4CD8+ MAIT cells between the subgroups of patients with ITP based on the response to treatment or the presence of Helicobacter pylori infection.

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posted on 08.11.2018, 19:01 by Takaaki Maekawa, Yukiko Osawa, Yosuke Okada, Noriaki Tachi, Masahiro Teramoto, Toshikuni Kawamura, Toshikatsu Horiuchi, Shoichiro Kato, Ayako Kobayashi, Shinichi Kobayashi, Ken Sato, Fumihiko Kimura

(A) The number of total MAIT, CD4CD8+ MAIT, and CD4CD8 MAIT cells in responders to prednisolone treatment [ITP patients achieving complete response (CR) and response (R)] (n = 7) and non-responders to prednisolone treatment [ITP patients exhibiting no response (NR) and loss of R] (n = 8). The non-responders exhibited a significantly lower number of total MAIT and CD4CD8+ MAIT cells than the responders. (B) The number of total MAIT, CD4CD8+ MAIT, and CD4CD8 MAIT cells in high responders to thrombopoietin receptor (TPO-R) agonist treatment [ITP patients achieving CR] (n = 11), and responders to TPO-R agonist treatment [ITP patients going no further than R] (n = 5). We found no significant changes in the number of total MAIT, CD4CD8+ MAIT, or CD4CD8 MAIT cells between the subgroups. (C) The number of total MAIT, CD4CD8+ MAIT, and CD4CD8 MAIT cells in patients with ITP with (n = 9, 8 of them were treated with prednisolone) or without (n = 9, seven of them were treated with prednisolone) H. pylori infection. We found no significant changes in the number of total MAIT, CD4CD8+ MAIT, or CD4CD8 MAIT cells between the two subgroups. Statistical significance was calculated by the Mann–Whitney U test, *p < 0.05.

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