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Comparison of the Na binding sites in the LeuTAa (dark grey) and dDaT (light grey) crystal structures and the GlyT2 model (colored helices).

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posted on 2016-06-23, 07:07 authored by Nandhitha Subramanian, Amanda J. Scopelitti, Jane E. Carland, Renae M. Ryan, Megan L. O’Mara, Robert J. Vandenberg

Crystallographic Na+ from the LeuTAa Na1 and Na2 sites are shown as dark grey spheres. The three modeled Na+ in GlyT2 are colored purple. Na+ occupies the Na1 and Na2 sites, and the proposed Na’ site of GlYT2. The substrate glycine is shown in CPK spacefill.