Comparison of noise reducing and signal transducing performance of the best performing FFL motifs.

The best performing simple and combined FFL networks are plotted in (A). The corresponding panels with similar layout (B-J) show the performance of each of these networks for the input change presented in Fig 1F. The mean of the output active forms of Z molecules of panel A are plotted with solid blue lines, ± standard deviation is plotted with shading, and coefficient of variation in percentage (% CV) values and slopes of input-output relation curves are labeled on all plots. All simulations were run with one-step post-translational modification models and the fixed parameter sets presented in the S1 Text.