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Comparison of minimum tumour load during treatment and the relapse time when tumour load surpasses the pre-treatment maximum for different sequential treatment schemes.

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posted on 12.02.2021, 18:41 by Michael Raatz, Saumil Shah, Guranda Chitadze, Monika Brüggemann, Arne Traulsen

Alterations between the trait-independent and the trait-dependent treatment type are fixed in the predefined sequence scheme (red to blue colour gradient corresponds to proportion of trait-dependent treatment type). In the realistic adaptive scheme, the currently best treatment type is determined at regular intervals during the treatment phase (grey colour gradient). In the optimal adaptive scheme (black dot), the treatment type that, given the current trait distribution, would exert the highest population mortality is chosen nearly instantaneously (at every step of the numerical solver). Note that these schemes have a much stronger impact on the minimal tumour load (up to a factor of 1000) than on the relapse time (up to a factor of 1.3).