pcbi.1009417.s012.eps (48.52 kB)
Comparison of experimental and simulated MDK99 of the evolved population after 10 cycles of exposure.
figureposted on 2021-09-23, 17:45 authored by José Camacho Mateu, Matteo Sireci, Miguel A. Muñoz
For both the additive and multiplicative cases, we observe that the simulated MDK99 falls within—or it is very close—the experimental values (i.e. the mean plus error) for Ta = 3h and 5h, but outside for the case of Ta = 8h. This result is to be expected given the higher noise of the experimental measurements. In particular the experimental mean is higher than the theoretical prediction of 8h.
xlink "> ecologicalskewed heavy tailssheds light ontoparent 8217key empirical observationsbroadly separated timescalesstress 8212reproduce quite wellphenotypic variations growsmodel 8212based model mimickingmathematical framework designeddistribution develops rightactual demographic processesintrinsic lag timesingle phenotypic traitnowadays wellexposure timestochastic modelwork representsutmost relevancetwo typestraditionally assumedthus pavingtackle muchrapid evolutionpopulation geneticsperiodically exposedparsimonious individualmacroscopic equationlaboratory conditionskimura equationintersperse muchindividual bacteriahistorically regardedgood accuracyexperimental setupevolutionary problemsevolutionary dynamicsdormant statedesign strategiesdependent variabilitycomputational approachescommunity remainbroader perspectivebiological mechanismsbacterial populationsaverage valueapproximately fitantibiotic stress