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Comparing C. muridarum recoveries from vaginal swabs of mice with or without deficiency in STING following a transcervical inoculation.

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posted on 2017-08-10, 18:16 authored by Yuyang Zhang, Lili Shao, Xiaodong Li, Guangming Zhong

Groups of C57BL/6J (solid bar or, solid square, n = 10) and STING-deficient (open bar or open square, n = 10) female mice were each inoculated with 2 x 105 IFUs transcervically and at various times after the inoculation as indicated along the X-axis, vaginal swabs were taken for titrating infectious organisms as displayed in Log10 IFUs (left) or % of mice with positive IFU (right) along the Y-Axis. Please note that there is no significant difference in either log10 IFUs (Wilcoxon) or % of mice with positive IFUs (Fisher’s Exact) between the wild type and STING-deficient mice (data obtained from two independent experiments), indicating that the STING-deficiency did not affect the descending of the C. muridarum organisms from the endocervcal compartments into the ectocervical and vaginal compartments or the replication of the C. muridarum organisms in these compartments.