pcbi.1008873.s005.png (2.2 MB)
Closeup structural view of the active site of HIV-1 RT.
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posted on 2021-08-26, 17:49 authored by Luc Blassel, Anna Tostevin, Christian Julian Villabona-Arenas, Martine Peeters, Stéphane Hué, Olivier GascuelThe p66 subunit is colored in dark gray, the p51 subunit in light gray. The active site is highlighted in blue. The NNIBP is colored in yellow. L228, E203 and D218 (red) are also very close on either side of the active site.
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using machine learningreverse transcriptase inhibitorresults likely indicateregulatory binding pocketmachine learning methodslow genetic barrierimportant representation featuresbinary representation features1 reverse transcriptaseknown drm featuresindependent data setssignificant frequency differences000 ), usingreveal new drmsremoving features correspondingnewly discovered drmsdrug resistance landscapequality sequence datarti )- experiencedrt active siteknown resistance signalremoving either featuresfind novel drmshiv significant signalknown drmsbig datasequence datasetn epistasis ),potential drms≈ 55xlink ">treatment pressurethus validatingspatially closesequences containingsamples associatedprediction accuracynaive samplesnaive patientslarge hivgrowing quantitycommonly transmittedcannot hope
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