ClfB contributes to virulence during S. aureus SSTI.
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BALB/c mice were infected subcutaneously with 2x107 CFU S. aureus LAC::lux or LAC::lux ΔclfB and abscess lesion size and bacterial burden was measured. Representative lesions from the dorsal area of mice from each group are shown (A) and results are expressed as total lesion size (cm2) ± SEM (B). Bioluminescence imaging was carried out using a Photon Imager and representative in vivo bioluminescence images are shown (C). Results are expressed as mean total photon flux (photons per second per steradian) ± SEM (D). Bacterial burden in the skin was assessed by viable counting on day 3 (E) and day 6 (F) post-infection. Results are expressed as Log10 CFU/mg. n = 9–10 per group. Data pooled from 2 independent experiments. Two-way ANOVA with Bonferroni post-test (B) and Mann-Whitney U test (E, F) used to analyse differences between groups. * P < 0.05, ** P < 0.01, *** P < 0.001.