Cerebral acidosis induced by graded normoxic hypercapnia.
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(A) pHbrain changes during graded normoxic hypercapnia induced by ventilation with 5–20% CO2 followed by restoration of normocapnia (grey lines–individual tracings, bold black line–mean). (B) Simultaneous reductions in pHa and pHbrain during graded normoxic hypercapnia were in accordance with the elevations in PaCO2, the values were (mmHg) 5%: 59.6±7.8, 10%: 84.7±9.0, 15%: 107.0±6.7, 20%: 120.3±8.2, (mean±SEM; n = 3). Corresponding PaO2 values were (mmHg) 5%: 75.5±12.8, 10%: 78.2±11.3, 15%: 85.5±8.2, 20%: 84.5±9.8, (mean±SEM; n = 3). (C) Linear regression shows close correlation between PaCO2 and pHbrain (R2 = 0.8546) values obtained during graded hypercapnia (5–20% CO2).