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CD4+ T cell populations in cancer septic animals exhibit increased coinhibitory receptor expression relative to previously healthy septic controls.

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posted on 2018-01-16, 18:38 authored by Jianfeng Xie, Jennifer M. Robertson, Ching-wen Chen, Wenxiao Zhang, Craig M. Coopersmith, Mandy L. Ford

CD4+ T cells isolated from splenocytes of previously healthy or cancer septic animals were analyzed for coinhibitory receptor expression by flow cytometry. A, Representative flow plots of LAG-3, BTLA, 2B4, and PD-1 expression. Frequencies (B) and absolute numbers (C) of LAG-3+, BTLA+, 2B4+, and PD-1+ CD4+ T cells from previously healthy vs. cancer septic animals. D, Representative flow plots of CD127 expression. MFI of CD127 expression on CD4+ T cells from previously healthy vs. cancer septic animals. n = 11/group. ***p<0.001, *p<0.05.

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