CD44 expression on T cells in mice lacking SOCS proteins.
(A) Representative flow cytometry profiles of CD8 and CD44 expression on TCRβ+ T cells in spleens mice 14d after tamoxifen or vehicle treatment. (B) Proportions of CD8+ T cells expressing high levels of CD44 (CD44hi) in spleens of mice at the times indicated after tamoxifen or vehicle treatment. (C) Proportions of naïve (CD44- CD62L+), central memory (CD44+ CD62L+) and effector memory (CD44+ CD62L-) CD3+ T cells in spleens of mice 50d (top panels) or 180d (bottom) after tamoxifen or vehicle treatment (m, moribund). Mean ± SD is shown with * p<0.05 for comparison of γS1S3 (moribund) with all genotypes at day 50 except γS1 (non-moribund day 50). ** p<0.05 for comparison of γS1 (moribund) with all genotypes at day 180 except γS1 (non-moribund, day 180), one-way ANOVA with Tukey’s multiple comparisons test, n = 7–20 mice per group.