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Bone damage caused by oncostatin M (OSM) in combination with either IL-1 or tumour necrosis factor alpha (TNF-α) in murine joints

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posted on 31.12.2011, 05:06 by Wang Hui, Tim E Cawston, Carl D Richards, Andrew D Rowan

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Taken from "A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL"

Arthritis Research & Therapy 2004;7(1):R57-R64.

Published online 10 Nov 2004

PMCID:PMC1064887.

Copyright © 2004 Hui et al., licensee BioMed Central Ltd.

Adenovirus vectors overexpressing murine OSM, IL-1 or TNF-α were injected intra-articularly into the right knee joints of mice at 5 × 10plaque-forming units [pfu]/vector/joint. The left knee joints were injected with the empty control vector. All joints received a total of 1 × 10pfu/joint, and all animals were sacrificed at day 7 following administration. Sections (5 μm) were stained with H&E. Control, OSM, IL-1, TNF-α, OSM + IL-1, and OSM + TNF-α. The joints showed a moderate (b–d) to severe (e–h) synovial hyperplasia and an infiltration of inflammatory cells. Marked synovial hyperplasia with angiogenesis was also seen with bone erosions (arrows) and bone fractures, with evidence of synovial invasion (e and g). b, bone; bm, bone marrow; f, bone fracture; m, muscle; s, synovial cells; v, blood vessel. (a)–(e), (g) Bar = 50 μm; (f), (h) bar = 20 μm.

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