Bioprinted 3D tissues treated with MASH induction media consisting of sugars and fatty acids result in steatosis as seen in the image on the right.
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posted on 2024-12-30, 18:31 authored by Vaidehi Joshi, Dwayne Carter, Alice E. Chen, Keith Murphy, J. William Higgins, Mediha Gurel, Daisy Chilin Fuentes, Sara Brin Rosenthal, Kathleen M. Fisch, Tatiana Kisseleva, David A. BrennerM–putative macrovesicular steatosis, m–putative microvesicular steatosis, B–putative ballooning hepatocytes.
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undergo histological processingtoxic fat moleculesmajor risk factordish &# 8221complex bioprinting platformnormal human livershepatic stellate cellsunderstanding mash pathogenesisbioprinted liver tissuesliver endothelial cellsliver tissues incubatedmash induction medialiver tissuesmash liversliver transplantationhealthy tissuescontrol medianonparenchymal cellskupffer cellscells purifiedmash phenotypemash ),sufficient sizepatients thusnonalcoholic steatohepatitislps ),leading causeimmunohistchemistry comparablehepatocellular carcinomafatty acidsdrug discoverycocktail consistingclosely resembledassociated steatohepatitis
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