Biomarkers with the best predictive ability to differentiate PHI from CHI-naïve individuals.
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The ability of each biomarker's first determination to distinguish between PHI patients and CHI-naïve was assessed via logistic regression models. Receiver operating curves (ROC) curves from univariate models were compared for the best prediction. Optimal threshold was determined through maximization of the nearest to (0,1) method. Sensitivity as true positive rate and Specificity as true negative rate. AUC as area under the curve.