Binding rate of the hexameric model (Model 6), γ_hexa.

All rate constants are normalized by k_h. (A-B) 2D plots of γ_hexa as a function of k_e and . The yellow region in (A) is magnified in (B). Blue and orange squares correspond to the best-fit parameters of KaiC-WT and KaiC-EE. Contours are plotted every 0.25 in (A) and 0.1 in (B). (C) The relaxation rate of Eq (11) γ_hexa (solid curve) and the coefficient α in Eq (12). (D) Percent error of the perturbative approximation of γ_hexa shown in Eq (13). Blue and orange squares are the same as (B). Contours are plotted every 0.2%.