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Download fileBAFF forms part of an amplification loop that is activated by inflammation
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posted on 2011-12-30, 23:26 authored by Meera Ramanujam, Anne DavidsonCopyright information:
Taken from "The current status of targeting BAFF/BLyS for autoimmune diseases"
Arthritis Research & Therapy 2004;6(5):197-202.
Published online 29 Jul 2004
PMCID:PMC546289.
Copyright © 2004 BioMed Central Ltd
Immune complexes induce interferon-α (IFN-α) secretion from plasmacytoid dendritic cells (DCs) that in turn stimulates myeloid dendritic cells to further activate T and B cells. Activated B cells act as effectors that secrete cytokines and chemokines, present antigen to T cells and migrate to inflamed tissues. Antagonism of T cell activation by dendritic cells or of B cell activation by T cells might synergize with BAFF blockade. APRIL, a proliferation-inducing ligand.
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