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BAFF forms part of an amplification loop that is activated by inflammation

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posted on 30.12.2011, 23:26 by Meera Ramanujam, Anne Davidson

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Taken from "The current status of targeting BAFF/BLyS for autoimmune diseases"

Arthritis Research & Therapy 2004;6(5):197-202.

Published online 29 Jul 2004

PMCID:PMC546289.

Copyright © 2004 BioMed Central Ltd

Immune complexes induce interferon-α (IFN-α) secretion from plasmacytoid dendritic cells (DCs) that in turn stimulates myeloid dendritic cells to further activate T and B cells. Activated B cells act as effectors that secrete cytokines and chemokines, present antigen to T cells and migrate to inflamed tissues. Antagonism of T cell activation by dendritic cells or of B cell activation by T cells might synergize with BAFF blockade. APRIL, a proliferation-inducing ligand.

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