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Azithromycin does not lessen disease severity of acute-experimental pancreatitis.

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posted on 10.05.2019, 17:27 by Sebastian Weis, Mario Heindl, Tania Carvalho, Elisa Jentho, Jana Lorenz, Ines Sommerer, Joachim Mössner, Albrecht Hoffmeister

(a) Representative images and (b) histopathological grading of pancreatic lesions 3 days after induction of AP or sham treatment of mice treated with azithromycin (AZM), ampicillin or saline. (c) Plasma amylase and (d) lipase at day three after AP induction. (e) Representative images of H&E stained lung sections of the same mice, and (f) histopathological grading of lung lesions (mean ± SD). Magnification as indicated 100x and 400x for pancreas and 200x for lung; H&E stained sections (a, e). Data is presented as mean±SD of six individual animals from six independent experiments. *p<0.5, **p<0.01, ***p<0.001, ****p<0.0001, n.s.: non significant. AZM: Azithromycin; SAL: saline.