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Average intoxication of N2 C. elegans (L4 stage) using five doses of pyrantel pamoate (PYR).

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posted on 2017-06-20, 17:30 authored by Kathryn J. Weaver, Cassandra J. May, Brian L. Ellis

a). Dead-Alive (1–0) scale. b). Health rating (3–0) scale. For comparative reference, the molar concentrations of each drug at 1000 μg/mL is indicated. Roundworms were scored daily for 7 days for motility. A score of 3 represented a worm with vigorous movement. A score of 2 represented a worm with whole body movements without external stimulus, but visibly slower than the control. A score of 1 represented a worm with movement only after the introduction of external stimulus. A score of 0 represented a worm with no movement, even after the introduction of external stimulus. To translate these scores into the binary dead or alive, a score of 3, 2, or 1 was considered a score of 1 (alive) and a score of 0 was considered a score of 0 (dead). Data are the combination of at least three independent trials.