Analysis of metabolomic alterations of the PML and control samples.

(A) Partial least squares discriminant analysis (PLS-DA) scores plot showing some separation between the PML (n = 23) and NPH (n = 8) subjects based on their metabolic profile of selected metabolites. (B) Concentrations of the 19 most promising metabolites (VIP>1). (C) Areas under the receiver-operating characteristic curves (AUROCs) of combinations of metabolites. (D) Variable influence on projection (VIP) plot showing the metabolites that are most important in driving the separation of the two groups.