Analysis of common variants within the DeCOI<sub>EUR</sub> cohort.
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posted on 2024-12-23, 19:01 authored by Axel Schmidt, Nicolas Casadei, Fabian Brand, German Demidov, Elaheh Vojgani, Ayda Abolhassani, Rana Aldisi, Guillaume Butler-Laporte, T. Madhusankha Alawathurage, Max Augustin, Robert Bals, Carla Bellinghausen, Marc Moritz Berger, Michael Bitzer, Christian Bode, Jannik Boos, Thorsten Brenner, Oliver A. Cornely, Thomas Eggermann, Johanna Erber, Torsten Feldt, Christian Fuchsberger, Julien Gagneur, Siri Göpel, Tobias Haack, Helene Häberle, Frank Hanses, Julia Heggemann, Ute Hehr, Johannes C. Hellmuth, Christian Herr, Anke Hinney, Per Hoffmann, Thomas Illig, Björn-Erik Ole Jensen, Verena Keitel, Sarah Kim-Hellmuth, Philipp Koehler, Ingo Kurth, Anna-Lisa Lanz, Eicke Latz, Clara Lehmann, Tom Luedde, Carlo Maj, Michael Mian, Abigail Miller, Maximilian Muenchhoff, Isabell Pink, Ulrike Protzer, Hana Rohn, Jan Rybniker, Federica Scaggiante, Anna Schaffeldt, Clemens Scherer, Maximilian Schieck, Susanne V. Schmidt, Philipp Schommers, Christoph D. Spinner, Maria J. G. T. Vehreschild, Thirumalaisamy P. Velavan, Sonja Volland, Sibylle Wilfling, Christof Winter, J. Brent Richards, André Heimbach, Kerstin Becker, Stephan Ossowski, Joachim L. Schultze, Peter Nürnberg, Markus M. Nöthen, Susanne Motameny, Michael Nothnagel, Olaf Riess, Eva C. Schulte, Kerstin U. Ludwig<p>(A) and (B): Manhattan plots of association analyses of single variants (MAF>0.5%) in DeCOI<sub>EUR</sub> (n = 1,017 individuals), for phenotype Ex (272 severely affected individuals vs. 362 mild controls) and B1 (655 hospitalized individuals vs. 362 non-hospitalized controls), respectively. Genomic inflation factors were 1.04 (Ex) and 1.00 (B1). Among the strongest associations is the well-established risk locus at 3p21.31. Panels (C) and (D) show the distribution of individual polygenic risk scores (PRS) among cases (orange or yellow) and controls (gray) of Ex (C) or B1 (D) overall (density plots in the left parts) or when stratified according to age below or above 60 years (box plots in the right parts). The elements of the box plots correspond to the following values: thick line: median, box: 25th and 75th percentile, whiskers: largest / smallest value not further away from the box than 1.5 times the interquartile range, points: values outside of the range of the whiskers. *: p<0.05, ***: p<0.001; Wald test followed by Bonferroni correction. MAF: Minor Allele Frequency.</p>
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- 1. DOI - Is supplement to Systematic assessment of COVID-19 host genetics using whole genome sequencing data
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whole genome sequencingsuggested nominal enrichmentsestablished risk geneentire frequency spectrumentire allelic spectrume ., europeans3p21 reaching genome220 mainly vaccineenabling joint analysesbased joint analyseslargest population subgroupsuggestive causal variantsdiv >< pcontrol analysesmale subgroupwide significancevariation acrosstlr7 </though researchsystematic assessmentstill lackingsignificantly youngerrare variantsoverall analysiskey locushighly variabledifferent typesdependent mannerburden testing2 infections2 infection
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