Analysis of ROC curves for the two DCE perfusion parameters, K<sup>trans</sup> and K<sub>ep</sub>, in the discrimination between low and high HIF-1α expression.
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posted on 2019-08-22, 17:33 authored by Auni Lindgren, Maarit Anttila, Suvi Rautiainen, Otso Arponen, Kirsi Hämäläinen, Mervi Könönen, Ritva Vanninen, Hanna Sallinen<p>The analysis reveals the diagnostic accuracy of A) K<sup>trans</sup> L-ROI (AUC = 0.832) B) K<sup>trans</sup> S-ROI (AUC = 0.840), C) K<sub>ep</sub> L-ROI (AUC = 0.808) and D) K<sub>ep</sub> S-ROI (AUC = 0.808). HIF-1α expression dichotomized into low and high using the median immunoreactive score as the cutoff value.</p>
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HIFpharmacokinetic DCE-MRI perfusion parameters0.832 K trans L-ROIOCK trans L-ROI P0.840 K trans S-ROIK epEES0.808 K ep L-ROIResults Pharmacokinetic perfusion parameters K transgadolinium-enhanced 3.0 T MRIK ep L-ROI Phypoxia-inducible factor 1Receiver Operating Characteristic curveextravascular extracellular spaceexpressionPharmacokinetic perfusion parametersmarkerAUCinfluences treatment responsemethods Thirty-eight patientsDynamic contrast-enhanced perfusion parameters
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