Altered expression of genes involved in the lipid metabolic pathway in response to the high phosphorous (HP) diet.
figureposted on 2016-05-17, 21:15 authored by Sunwoo Chun, Takeshi Bamba, Tatsuya Suyama, Tomoko Ishijima, Eiichiro Fukusaki, Keiko Abe, Yuji Nakai
The HP diet induced alterations in the hepatic expression of enzymes involved in lipid catabolism and biosynthesis. Enzymes and factors whose mRNA expression is higher and lower in the livers of HP diet-fed rats are shown in red and blue, respectively, in comparison to their expression in the livers of control diet-fed rats. See Table 1 for DEGs related to lipid metabolism. Up- and down-regulated pathways are represented with red and blue arrows, respectively. PUFA, polyunsaturated fatty acid; TCA, tricarboxylic acid.
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diet causes disorderstype IIb sodium-dependent phosphate transporterhepatic arachidonic acidHP dietDEGIngenuity Pathway Analysiscontrol diet-fed ratsadipose tissuePPAR α target geneGene Ontology analysisHP diet-fed ratsacid β- oxidation processperoxisome proliferator-activated receptorDNA microarray analysisHigh Phosphorus Diet Affects Lipid MetabolismRNADNA Microarray Analysisacid β- oxidation