Alteration in glioblastoma cancer stem cell signaling in response to growth factors withdrawal and differentiation in 2% FBS.
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posted on 2025-02-07, 18:40 authored by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F. . Petricoin III, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C. deCarvalhoA) Box plot representing changes in the levels of 66 proteins/PTM in response to 14-days culture in the absence of growth factors (NM), or upon serum differentiation (2�S), relative to CSC culture conditions (NMGF), using mean values from triplicate RPPA measurements for each of the 8 models. Plot represents n = 507 data points, after proteins/PTMs which were not detected under all three culture conditions were filtered out for each model.
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xlink "> glioblastomasignificant intratumoral heterogeneityprovides valuable insightskey stemness genesincluding targeted proteomicsalkylating agent temozolomideidentified tp53 statusclinical studies aimednf -&# 954glioblastoma cell responsedna methylation profilingdamage associated interferonsmad signaling pathwayp53 gbm cellsp53 statusinterferon signalingdifferentiated cellsclinical potentialkb signalingtreatment modalitytranscriptional responsetranscriptional diversitysurvival pathwaysrepresentative panelpositively correlatedomics approachmolecular diversityintegrative multiintegrative analysisincreased resistancegbm treatmentgbm responsedna methyltransferasedifferentiation statedevelopmental statecritical determinantastrocytic differentiationalso modulated
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