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Allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma-2

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posted on 31.12.2011 by Michael G Anderson, K Saidas Nair, Leslie A Amonoo, Adrienne Mehalow, Colleen M Trantow, Sharmila Masli, Simon WM John
T an average IOP typical of many non-glaucomatous mouse strains. As previously described, D2 mice (homozygous for the mutation) exhibit an elevated IOP at 10 mo of age, as do D2 mice receiving syngeneic bone marrow transfers (R150X → R150X). Chimeric mice in which D2-bone marrow has been transferred into D2 hosts (WT → R150X) continue to maintain non-glaucomatous IOP values, whether examined at 10 mo, or beyond. The IOPs of both mice and chimeric mice with bone marrow were significantly lower than those of all mice with mutant marrow (P < 0.002 for all comparisons at various ages, test).

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Taken from "allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma"

http://www.biomedcentral.com/1471-2156/9/30

BMC Genetics 2008;9():30-30.

Published online 10 Apr 2008

PMCID:PMC2373794.

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