Alignment of UNC-29 protein.
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posted on 2016-07-14, 11:49 authored by Thomas B. Duguet, Claude L. Charvet, Sean G. Forrester, Claudia M. Wever, Joseph A. Dent, Cedric Neveu, Robin N. Beech<p>Sequence for <i>C</i>. <i>elegans</i> is shown in reference to six representative paralogs from <i>H</i>. <i>contortus</i> and <i>O</i>. <i>dentatum</i>. The signal peptide is indicated in pink, four transmembrane regions in blue and the characteristic cys-loop in yellow. Amino acids under positive selection are indicated in green.</p>
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gene copiesreceptor assemblyanthelmintic drug targetsreceptors reconstitutedphenotype rescueCaenorhabditis eleganscodon substitution rate analysisacetylcholine receptorssubunits co-expressedRecent DuplicationXenopus oocytesnematodeacetylcholine receptor subunit genesFunctional Divergencenovel drug targetssubunit duplicationfast-synaptic transmissionclade Vgenome dataHaemonchus contortusunc -29acetylcholine receptor subunitacid positions25 speciesreceptor composition changesubunit compositionParasitic Nematode Levamisole-Sensitive Acetylcholine Receptors Helminth parasitesgene duplicationsubunit assemblypentameric levamisole-sensitive acetylcholine receptor50 helminth genome initiative
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