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Additional file 5 of Quantifying the potential value of antigen-detection rapid diagnostic tests for COVID-19: a modelling analysis

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posted on 09.03.2021, 04:39 by Saskia Ricks, Emily A. Kendall, David W. Dowdy, Jilian A. Sacks, Samuel G. Schumacher, Nimalan Arinaminpathy
Additional file 5: Figure S2. Relative value of Ag-RDT-led vs NAT-based testing, for averting deaths in a hospital setting. The figure shows the same results as those presented in Fig. 2 in the main text, but here assuming that all patients awaiting a NAT result (whether as part of a NAT-based strategy or for confirmation of Ag-RDT results) were not isolated during this time. Results illustrate qualitatively similar findings to those shown in the main text. In panel (A), in the scenario where Ag-RDT-negative results were confirmed using NAT (red points), 57% of simulations placed the Ag-RDT-led strategy in the favourable region, below the diagonal dashed line. Panels (B, C) show additional sensitivity analyses for these points in particular, as described in Fig. 2. In (C), red lines show 75% NAT availability (vertical line), and 90% sensitivity of clinical judgement (horizontal line). In the lower left quadrant of these lines, an Ag-RDT was favourable over NAT in 85% of simulations.

Funding

Foundation for Innovative New Diagnostics Wellcome Trust UK Medical Research Council Department for International Development, UK Government

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