13045_2020_1029_MOESM4_ESM.tif (2.62 MB)
Download file

Additional file 4 of STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib

Download (2.62 MB)
posted on 15.01.2021, 04:26 by Yahui Zheng, Chong Huang, Lu Lu, Kangkang Yu, Jing Zhao, Mingquan Chen, Lu Liu, Qingfeng Sun, Zhifei Lin, Jianming Zheng, Jinhong Chen, Jubo Zhang
Additional file 4: Figure S2. STOML2 expression is upregulated in HCC cells, promotes HCC proliferation and inhibits apoptosis in vitro. (A–B) Expression of mRNA (A) and proteins (B) levels of STOML2 in different HCC cell lines. Significantly increased STOML2 levels were detected in HCC cell lines especially in those with higher invasive and metastatic capabilities cells (MHCC-97H and HCCLM3) compared with L02. (C–D) The effects of STOML2 gain- or loss-of-function on in vitro proliferation (C) and apoptosis (D) by colony formation assay and flow cytometric analysis. *P<0.05; **P<0.01; ***P<0.001; ns, no significance.


National Natural Science Foundation of China (CN) National Natural Science Foundation of China Natural Science Foundation of Shanghai Zhejiang Province Public Welfare Technology Application Research Project National Key Scientific Instrument and Equipment Development Projects of China