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Additional file 4: Figure S4. of Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal

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posted on 20.04.2017, 05:00 by T. Walter, Fulton Crews
Acute binge ethanol withdrawal increases brain TNFα, Ccl2, and IL-4 mRNA compared to controls. Mice were gavaged with acute binge ethanol (6 g/kg, 25% v/v) or water and sacrificed various times post-treatment. A) Brain TNFα, B) Ccl2, C) IL-1ra, and D) IL-4 were measured over time by RT-PCR in both water- and ethanol-treated mice. Data are represented as mean ± SEM. *p < 0.05 compared to controls. n = 5–7/group (TIF 136 kb)


National Institute on Alcohol Abuse and Alcoholism