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Additional file 3 of Native contrast visualization and tissue characterization of myocardial radiofrequency ablation and acetic acid chemoablation lesions at 0.55 T

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posted on 2021-05-06, 03:38 authored by Aravindan Kolandaivelu, Chris G. Bruce, Rajiv Ramasawmy, Dursun Korel Yildirim, Kendall J. O’Brien, William H. Schenke, Toby Rogers, Adrienne E. Campbell-Washburn, Robert J. Lederman, Daniel A. Herzka
Additional file 3: Figure S2.Visual correlation of RF ablation and chemoablation lesions acutely on Day 0 after ablation using gross photography, native contrast CMR and histological stains. Gross photography (a) compares very well with CMR (b) as shown by the overlay of the two (a + b). RF ablation (green arrows) and chemoablation (orange arrows) lesions are clearly seen including the boundary between T1w enhancing and non-enhancing portions of RF ablation lesions. This boundary can also be visualized on histological stains (c, d). Chemoablation lesions do not exhibit a significant non-T1w enhancing peripheral zone. The areas of necrosis can be visualized as purple in Masson’s Trichrome stain, while small pockets of blood can be most easily visualized in the H&E stain. The hypointense cavity within the septal RF ablation lesion is due to a “steam-pop” resulting from tissue overheating. Overall, there is excellent correlation between areas of T1w enhancement and the inner portion of the necrotic core of lesions.


National Heart, Lung, and Blood Institute