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Additional file 2: of Deletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy

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posted on 17.01.2017, 05:00 by Nora Huang, Melanie Kny, Fabian Riediger, Katharina Busch, Sibylle Schmidt, Friedrich Luft, Hortense Slevogt, Jens Fielitz
Polymicrobial sepsis increases Nlrp3, Il1b, and Il6 expression in the muscle. Twelve-week-old male C57B16/J mice were subjected to cecal ligation and puncture (CLP) or sham surgery (sham), as indicated. (A) qRT-PCR analysis of Nlrp3, IL-1β, and Il6 expression in gastrocnemius/plantaris (GP) and (B) tibialis anterior (TA) muscles of sham (n = 5) and CLP (n = 5) mice 4 days after surgery. mRNA expression was normalized to Gapdh. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. (EPS 1161 kb)


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