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Additional LANA expression is not sufficient for the early recruitment of EZH2 onto the KSHV genome.

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posted on 2016-09-08, 04:30 authored by Zsolt Toth, Bernadett Papp, Kevin Brulois, Youn Jung Choi, Shou-Jiang Gao, Jae U. Jung

(A) Time course analysis of LANA protein expression during de novo infection. (B) Time course ChIP analysis of LANA-binding to viral promoters during de novo infection. (C) Immunoblot analysis of LANA expression in empty lentiviral vector and 3xFLAG-LANA expressing lentivirus infected cells. (D) ChIP assays for binding of LANA and EZH2 to viral promoters in LANA-overexpressing cells during de novo KSHV infection.

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