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Adding synaptic input to the oxytocin neuron HH model.

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posted on 06.07.2017 by Trystan Leng, Gareth Leng, Duncan J. MacGregor

(A) The original oxytocin HH model, challenged with a constant applied current of 4.5 nA produces regular firing at 10 spikes/s; each spike is followed by a conspicuous but short HAP. (B) shows the HH model with EPSCs at 600 Hz (Repsc = 600, Ripsc = 0), generating spikes at a mean rate of 5.6 spikes/s. The randomly timed EPSCs generate a noisy spiking membrane potential that much more closely resembles an in vivo neuron than the regular spikes produced by an applied current. Note that the post-spike HAP is less conspicuous and of more varied appearance than in A. (C) shows the HH model with EPSCs at 600 Hz, and IPSCs at 300 Hz (Repsc = 600, Ripsc = 300), generating spikes at a mean rate of 1.6 spikes/s. Note that the HAP following spikes is even less conspicuous than in B.

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