pgen.1008063.g008.tif (561.7 kB)

A regulatory model for the formation of sexually dimorphic horns in T. dichotomus.

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posted on 2019-04-10, 17:36 authored by Shinichi Morita, Toshiya Ando, Akiteru Maeno, Takeshi Mizutani, Mutsuki Mase, Shuji Shigenobu, Teruyuki Niimi

In males, default splicing generates Tdic-dsxM, whereas in females, Tdic-tra (a female isoform, traF) and Tdic-tra2, generates Tdic-dsxF by female-specific splicing of Tdic-dsx pre-mRNA. Prepupal Tdic-dsxM expression in males positively regulates the growth of head and thoracic horn primordia, whereas prepupal Tdic-dsxF in females suppresses the horn growth activity. In pupa, Tdic-dsxM regulates thoracic horn remodeling, but is dispensable for remodeling of head horn. GRN, gene regulatory network.