ATAC-seq shows that T cells contain regions of open chromatin that lie outside the region of the BACtg.

figure

posted on 2025-03-07, 18:26 authored by Alyssa Kearly, Prontip Saelee, Jonathan Bard, Satrajit Sinha, Anne Satterthwaite, Lee Ann Garrett-Sinha

(B) ATAC-seq profiles for B cells, CD4 T cells, and CD8 T cells within the Ets1 sub-TAD. The genomic region contained in the BAC transgene is highlighted in yellow. Highlighted in aqua are accessible sites outside of the BAC that may be T cell-specific Ets1 response elements.

(TIF)

History

Usage metrics

Keywords

prevent premature activation using reporter constructs compile epigenetic datasets div >< p genetic regulatory elements dna sequences within 100 kb upstream stimulated b cells transcription factor ets1 high dna accessibility reduced ets1 expression cells mouse b cells gene expression levels sequences within regulatory elements b cells reporter gene ets1 ets1 transcription epigenetic landscape gene expression b cell transcription factors secreting cells variegated expression specific expression control expression consistent expression gene body ets1 serves undergo changes transgenic mice tlrs ).taken together studies reveal stringent control performed atac mice leads lymphoid tissues like receptors interaction hub important roles immune response identifying regions human pbmcs high level functional redundancy functional analysis complex network chromatin accessibility autoimmune syndrome autoimmune diseases associating domain antigen receptors analysis indicates

Licence

CC BY 4.0

ATAC-seq shows that T cells contain regions of open chromatin that lie outside the region of the BACtg.

History

Usage metrics

Categories

Keywords

Licence

Exports