1866 and DANA effects on MCD-induced changes in white adipose tissue.

A-H) Representative images of epididymal white fat sections of A-D) C57BL/6 mice or E-H) or db/db mice, on A and E) control diet, B and F) MCD diet, C and G) MCD+1866, or D and H) MCD + DANA were stained with hematoxylin and eosin. Images are representative of three to five mice per condition. Bar is 0.1 mm. Average adipocyte area was calculated for I) C57BL/6 and J) db/db mice. K) Crown like structures (CLS) in white fat were counted for C57BL/6 and db/db mice. Values are mean ± SEM, n = 3–5 mice per group. * indicates p < 0.05 (one-way ANOVA, Sidak’s test) or ## p < 0.01, ### p< 0.001 indicates comparing C57BL/6 and db/db mice on control or MCD diet (t test).