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() Schematic diagram of the domain structure of human poly(C) binding protein-2 (PCBP2)

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posted on 31.12.2011, 07:18 by Sebastian Fenn, Zhihua Du, John K. Lee, Richard Tjhen, Robert M. Stroud, Thomas L. James

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Taken from "Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 Å resolution"

Nucleic Acids Research 2007;35(8):2651-2660.

Published online 10 Apr 2007

PMCID:PMC1885661.

© 2007 The Author(s)

Similar domain structures are observed in other members of the PCBP family. () Sequence alignment of the three KH domains from different PCBPs. Alignments were carried out using the program ClustalX. The sequence shown for PCBP2 KH3 corresponds to residues 285–359 in the full-length protein. The actual construct for crystallization has an artificial lysine before Ala285. Secondary structures of the KH3 domain were based on the crystal structure.

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