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() Crystal structure of a 16mer DNA duplex in complex with the N-terminal fragment of Moloney murine leukemia virus reverse transcriptase

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posted on 31.12.2011, 02:55 by Sherwin P. Montaño, Marie L. Coté, Monica J. Roth, Millie M. Georgiadis

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Taken from "Crystal structures of oligonucleotides including the integrase processing site of the Moloney murine leukemia virus"

Nucleic Acids Research 2006;34(19):5353-5360.

Published online 26 Sep 2006


© 2006 The Author(s)

The ribbon-rendering was done with MOLSCRIPT (). The DNA structure shown here is that of the LTR-A. The asymmetric unit in this lattice contains one protein molecule and one-half the DNA molecule. The dashed line marks the crystallographic 2-fold axis. () The LTR-A, -B, -C and -D sequences for which we have determined crystal structures are shown. These sequences are derived from the 3′-processing site of the actual LTR. The bases underlined are those in common with the actual LTR sequence. In LTR-B, the eight base-pairs that are boxed in is the LTR-LTR junction and outlined with a darker box is the CA cut site. The numbering scheme for the bases is shown in the LTR-A sequence. () The structures of LTR-A (orange), -B (blue and red), -C (black) and -D (green) are shown as stick renderings. Arrows indicate the site of cleavage immediately 3′ of the CA dinucleotide step.