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mSigDB “MUELLER_PLURINET” gene list.

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posted on 2021-11-11, 18:25 authored by Ralitsa R. Madsen, Emily C. Erickson, Oscar M. Rueda, Xavier Robin, Carlos Caldas, Alex Toker, Robert K. Semple, Bart Vanhaesebroeck

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Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype
PLOS GeneticsPLOS Genetics

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tumor samples withoutgene encoding p110αencompassing nearly 3div >< p000 tumor sampleshuman cell modelpositive linear association>< sup ><patient stratification basedbased analysis uncoveredhuman breast cancerhotspot mutations correlatedmtor signaling scoresmtor signalingbreast cancerhuman tumors></ supsignaling strengthaggressive cancertumors accordingtranscriptomic stemnesstranscriptomic indicestranscriptional footprintsupports evaluationstemness scoresstemness relationshipsingle copyselective inhibitorprovides evidencepreclinical studiespotential benefitpositive correlationpik3ca </multiple copiesh1047r </direct evidencecounterintuitive relationshipallele dosage

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