eIF6 deficiency alleviates colorectal cancer through maintaining the intestinal barrier and homeostasis of gut microbiota

In this study, we demonstrate the mitigating effect of eIF6 deficiency on the progression of CRC in an AOM/DSS-induced mouse model, elucidating how eIF6 deficiency directly alleviates CRC progression through its impact on the gut microbiota. We observe that eIF6 deficiency promotes colonic epithelial regeneration, maintains intestinal barrier integrity, and suppresses tumor proliferation in CRC mice. The eIF6 deficiency-modulated gut microbiota directly contributes to alleviating CRC progression. Furthermore, eIF6 deficiency-dependent Dubosiella newyorkensis reduces monocyte aggregation, inhibits the MAPK and NF-κB carcinogenic pro-inflammatory pathways, thereby attenuating CRC progression. These findings confirm the pivotal role of the gut microbiota in mediating the alleviation of CRC progression of eIF6 deficiency.